ANANDHAKUMAR JAYAMANI
Lancaster
Summary
Friendly Scientist with a focus of interest. Excellent strategic planning, communication, and relationship building expertise.
Overview
21
21
years of professional experience
Work History
Principal Scientist II, Cell And Gene Therapy
EUROFINS
Lancaster
11.2021 - 08.2025
- Knowledge on use of electronic lab notebook(ELN) and laboratory information management system(LIMS).
- Validation of a Platform Method for Quantification of Cell Lines (Invovled in Experimental desgin and generations of lab results).
- Protocol, SOPs and Client Parameter Sheet writing.
- Client CAR-T Tech Transfer on Cell Viability and Quantification Assay feasibility (Accuracy, Linearity, Precisison and Stability parameter tested) and cGMP testing performed.
- Gained some working expereince on Flow Cytometry: BD FACSLyric.
- Compendial Testing (Visible Particles, pH, Apperance and Extractable Volume).
- Viral Vector Safety Testing cGMP Validation (Cell Based Replication Competent Virus Assay: 1. rcAAV with qPCR endpoint ) and gainned knowleadge on 2. RCA with CPE under Microscopy 3. RCL with p24 ELISA.
- AAV Infectious titer assay: Cell based with qPCR End point.
- Participated in client call and result presentations.
- Exposed to Issue resolution: Exceptions, root cause analysis and CAPAs.
- Learned BioRad ddPCR for AAV quantification testing.
- Invovled in Transmission Electron Microscopy and Mass Photometer for the Full and Empty AAV study.
- Particapted in Cell and Gene Therapy department establishment by onboarding instruments which meets the FDA compliance (21 CFR Part 11).
Postdoctoral Research Associate
UNIVERSITY OF PITTSBURGH
Pittsburgh
01.2019 - 10.2021
- Leading a project on the mechanism and regulation of RNA Polymerase II Elongation.
- Design and conduct innovative research projects on diverse subjects while also collaborating with principal investigators, postdoctoral researchers and graduate students on a number of additional projects.
- Develop high-proficiency in utilizing core molecular biology, cell-based assays, cell culture and high-throughput screening techniques for critical project functions.
Postdoctoral Fellow
LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER
Shreveport
01.2013 - 01.2017
- Studied complex chromatin, transcription and epigenetics issues to support numerous biochemistry and molecular biology research efforts, which attracted a grant where I served as Lead Post-doctoral fellow: Gene Regulation in Response to Heat Stress; National Science Foundation (MCB-1518345); Total Costs: $510,000; Funding Period: 9/1/15 - 8/31/18.
- Assumed a leadership role in the lab in place of Dr. Gross while he was on sabbatical at MIT (2015/2016).
- Provided comprehensive training to undergraduate students in molecular biology techniques to enhance their skills and performance.
- Analyzed complex data and accurately documented/presented project results in group meetings.
Postdoctoral Fellow
UNIVERSITY OF NAMUR
Namur
01.2011 - 01.2013
- Investigated the regulation of the RNA polymerase II CTD to identify core issues and enhancements.
- Executed a variety of research projects leading to numerous peer-reviewed publications.
- Delivered full assistance for technology development proposals.
Scientific Research Associate
KATHOLIEKE UNIVERSTIET
Leuven
01.2009 - 01.2011
- Utilized yeast as a model system to evaluate and analyze various facets of tau biology assuring optimal project success.
Postdoctoral Fellow
UNIVERSITÉ PARIS XI
Paris
01.2007 - 01.2008
- Coordinated and conducted extensive research on Ribosome Biogenesis guaranteeing on-time project delivery.
- Complied with all safety policies, practices and procedures within the lab.
- Maintained detailed records of results including collecting, extracting and entering data and preparing graphs.
Scientific Research Associate
LEIBNIZ-INSTITUTE FOR AGE RESEARCH
Jena
01.2005 - 01.2007
- Performed thorough research on motor proteins and microtubules in support of sophisticated scientific research initiatives.
Education
Doctor of Philosophy - Plant Microbial Interactions
University of Hannover
Hannover, GermanyMaster of Science - Applied Plant Science
University of Madras
Chennai, IndiaBachelor of Science - Microbiology
A. V. S College of Science
Salem, IndiaSkills
- Gene And Cell Therapy
- Molecular Biology
- Microbiology
- Next-Generation Sequencing
- Scientific literature
- Epigenetics
- Cell culture assays
- Viral/Yeast/Bacterial
- Nucleic acid and protein extraction
- QPCR
- CRISPR-Cas9 mediated genome editing
- HR mediated genome editing
- Chromatin Immuno precipitation (ChIP)
- Live mRNA reporter assay
- Western blot
- Southern blot
- Northern blot
- Tetrad dissection
References
DETAILED REFERENCES AVAILABLE UPON REQUEST
Selected Publications
- Perturbations of Transcription and Gene Expression-Associated Processes Alter Distribution of Cell Size Values in Saccharomyces cerevisiae., G3 (Bethesda), 01/09/19, 9, 1, 239-250
- Genetic and Epigenetic Determinants Establish a Continuum of Hsf1 Occupancy and Activity Across the Yeast Genome., Mol Biol Cell, 12/15/18, 29, 26, 3168-3182
- Evidence for Multiple Mediator Complexes in Yeast Independently Recruited by Activated Heat Shock Factor., Mol Cell Biol, 06/29/16, 36, 14, 1943-60
- Promoter nucleosome dynamics regulated by signalling through the CTD code., Elife, 06/22/15, 4, e09008
- Uncoupling transcription from covalent histone modification., PLoS Genet, 04/10/14, 10, 4, e1004202
- Regulation of entry into gametogenesis by Ste11: the endless game., Biochem Soc Trans, 12/01/13, 41, 6, 1673-8
- Yeast as a model system to study tau biology., Int J Alzheimers Dis, 04/06/11, 2011, 428970
- Biological control of red stele (Phytophthora fragariae var. fragariae) and crown rot (P. cactorum) disease of strawberry with rhizobacteria., Journal of Plant Diseases and Protection, 01/01/08, 115, 2, 49-56
Personal Information
Residency: U.S. permanent resident/Green Card holder
Timeline
Principal Scientist II, Cell And Gene Therapy
EUROFINS
11.2021 - 08.2025
Postdoctoral Research Associate
UNIVERSITY OF PITTSBURGH
01.2019 - 10.2021
Postdoctoral Fellow
LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER
01.2013 - 01.2017
Postdoctoral Fellow
UNIVERSITY OF NAMUR
01.2011 - 01.2013
Scientific Research Associate
KATHOLIEKE UNIVERSTIET
01.2009 - 01.2011
Postdoctoral Fellow
UNIVERSITÉ PARIS XI
01.2007 - 01.2008
Scientific Research Associate
LEIBNIZ-INSTITUTE FOR AGE RESEARCH
01.2005 - 01.2007
Doctor of Philosophy - Plant Microbial Interactions
University of Hannover
Master of Science - Applied Plant Science
University of Madras
Bachelor of Science - Microbiology
A. V. S College of Science