MICHELLE FRASCELLA
Wayne
Summary
Professional scientist prepared for advanced research roles. Proven ability to lead and collaborate in multidisciplinary teams, driving impactful results. Skilled in experimental design, data analysis, and scientific writing. Adaptable, reliable, and focused on achieving meaningful outcomes in dynamic environments.
Overview
27
27
years of professional experience
1
1
Certification
Work History
Sr Research Scientist, Pharmacology
INCYTE CORP
08.2019 - Current
- Coordinate in-vivo research support and managing study logistics. Writing study protocols, formulating compound and animal dosing for PK and PD studies within the Oncology group.
- Cell culture and Xenograft model development.
- Perform multiple routes of dosing for rats and mice as well all types of tissue collections.
- Perform MSD, HTRF and qPCR assays and analysis.
- Writing reports for IND submission.
- Serves as 3R’s representative on IACUC
Sr Scientist I, Pharmacology
AMICUS THERAPEUTICS
11.2007 - 08.2019
- Coordinate in-vivo research support and managing study logistics for biologics and gene therapy within the rare disease space. Writing study protocols, formulating compound, animal dosing for pharmacokinetic, and efficacy studies.
- Perform multiple routes of dosing for rats and mice as well all types of tissue collections.
- Design in vivo studies and trouble shoot for optimal operations of study conduct.
- Study management.
- Assist with biochemical assays.
- Perform study tissue preparation for bio-chemical and bio-analytical.
- Skilled at working in a fast-paced environment and meeting deadlines on time.
- Perform data analysis using Phoenix 6.1 WinNonLin as well as Graphpad Prism 6
- Writing reports for IND submission.
- Presenting data to group and companywide meetings.
- Supervising one direct report.
Associate Scientist, ADME
JNJ PRD
08.2005 - 11.2007
- Perform rat, mouse, dog and non-human primate pharmacokinetic studies. Including tissue distribution and blood-brain barrier studies.
- Conducted study prep such as protocol writing as well as data analysis using WinNonLin 5.1.
- Wrote and issued data reports to program teams.
- Served as an “ADME representative”, interacted, and built communication with project teams.
Scientist, Preclinical DMPK
GLAXOSMITHKLINE PHARMACEUTICALS
11.2001 - 08.2005
- Served as study director conducting rat, mouse, dog and non-human primate pharmacokinetic studies.
- Wrote study protocols, dosed animals, collected blood and tissue samples.
- Proficient in the use of the Culex Automated Blood Sampling System.
- Surgically prepared femoral vein and artery cannulated rats.
- Data analysis using WinNonLin 4.1.
Research Assistant, Reproductive and General Toxicology
KELLY TEMP (JNJ)
10.2000 - 11.2001
- Assisted with study protocols and study set up according to GLP requirements.
- General handling, restraint and dosing of rabbits, rats and dogs.
- Bleeding of rabbits via the medial ear artery.
- Bleeding dogs via the jugular and cephalic vein.
- Perform necropsy of rats, rabbits and dogs.
- Collection of observations and raw data.
- Assisted with organizing data for final report.
Research Technician, Dr Dietmar Kappes Lab
FOX CHASE CANCER CENTER
03.1998 - 10.2000
- Bleeding and typing transgenic mice by Facscan.
- Tailing and typing transgenic mice by Southern Blot.
- Necropsy and collection of tissue samples
- General lab work and ordering of supplies.
Education
Bachelor of Science - Small Animal Science
DELAWARE VALLEY COLLEGE OF SCIENCE AND AGRICULTURE
Doylestown, PA01.1997
Skills
- Small and large in vivo dosing
- Study management
- Phoenix WinNonLin 61,
- Graphpad Prism 6
- Word, Excel, Power Point
- Experimental design
- Report writing
- Drug discovery
- QPCR
- HTRF
- MSD
Certification
- Clinical Trials Management certificate (2024)
Timeline
Sr Research Scientist, Pharmacology
INCYTE CORP
08.2019 - Current
Sr Scientist I, Pharmacology
AMICUS THERAPEUTICS
11.2007 - 08.2019
Associate Scientist, ADME
JNJ PRD
08.2005 - 11.2007
Scientist, Preclinical DMPK
GLAXOSMITHKLINE PHARMACEUTICALS
11.2001 - 08.2005
Research Assistant, Reproductive and General Toxicology
KELLY TEMP (JNJ)
10.2000 - 11.2001
Research Technician, Dr Dietmar Kappes Lab
FOX CHASE CANCER CENTER
03.1998 - 10.2000
Bachelor of Science - Small Animal Science
DELAWARE VALLEY COLLEGE OF SCIENCE AND AGRICULTURE
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