Prabesh Ghimire

Research Specialist with extensive experience at University of Pennsylvania, specializing in laboratory management. Demonstrated success in leading independent projects and mentoring students while ensuring meticulous record-keeping. Proficient in molecular biology techniques, cell culture, and animal research, supported by strong organizational and communication skills.

Best Presentation in Annual Biology Colloquium (2014), Texas State University-San Marcos, TX, Texas Public Educational Grant (2014) and (2015), Texas State University-San Marcos, TX, Associated Student Government Scholarship (2014) and (2015), Texas State University- San Marcos, TX, Certificate for Academic Excellence (2015), Texas State University- San Marcos, TX, Student Research Grant, Nepal Government Organization, (2010-2012), Kathmandu, Nepal.

• Wang C, Ghimire P, Winkelstein B. (2024). Collagen Organization in a model of facet capsular ligament modulates mechanics and regional collagen and neuronal responses after tensile loading. Biomedical Engineering Society. Baltimore, MD, USA
• Wang C, Meyers M, Ghimire P, Perez M, Winkelstein B. (2024). Characterization of the mechanical and compositional effects of MMP-9 exposure on neuron-collagen constructs: Implications for joint degeneration. Summer Biomechanics, Bioengineering, and Biotransport Conference. WI, USA
• Granquist E, Ghimire P, Winkelstein B. (2023). Evaluation of condylar remodeling and MMPs from patient with Temporomandibular Osteoarthritis. 8thInternational TMJ Interdisciplinary Research meeting. PA, USA
• Singh S, Ghimire P, Winkelstein B. (2022). Expression of The Injury Marker Activating Transcription Factor-3 After Exposure To MMP-1 Is Decreased In A Neuron Collagen Co-Culture With Phospholipase A2 Inhibition. Summer Biomechanics, Bioengineering, and Biotransport Conference. MD, USA
• Ghimire P, Kartha S, Zeeman M, Winkelstein B. (2021). Ketorolac Attenuates Pain & Reduces Spinal Glutamatergic Signaling Markers That Are Modulated With Painful Whole Body Vibration. Orthopedic Research Society
• Ita M, Ghimire P, Granquist E, Winkelstein B. (2020). MMP1 proteins levels in human TMJ ligament and dishes are differentially correlated with pain. Orthopedic Research Society.
• Ita M, Ghimire P, Winkelstein B. (2018). Painful Facet Joint injury increases Spinal MMP-1 early followed by later TIMP-1 gene expression in the Dorsal Root Ganglia. 17th World Congress on PAIN. Boston, MA. USA

• Ita ME, Ghimire P, Granquist EJ, Winkelstein BA. MMPs in tissues retrieved during surgery from patients with TMJ disorders relate to pain more than to radiological damage score. J Orthop Res. 2022;40(2):338-347. doi:10.1002/jor.25048
• Kartha S, Ghimire P, Winkelstein BA. Inhibiting spinal secretory phospholipase A2 after painful nerve root injury attenuates established pain and spinal neuronal hyperexcitability by altering spinal glutamatergic signaling. Mol Pain. 2021;17:17448069211066221. doi:10.1177/17448069211066221
• Ita ME, Ghimire P, Welch RL, Troche HR, Winkelstein BA. Intra-articular collagenase in the spinal facet joint induces pain, DRG neuron dysregulation and increased MMP-1 absent evidence of joint destruction. Sci Rep. 2020;10(1):21965. Published 2020 Dec 15. doi:10.1038/s41598-020-78811-3
• Sperry, M. M., Yu, Y. H., Kartha, S., Ghimire, P., Welch, R. L., Winkelstein, B. A., & Granquist, E. J. (2020). Intra-articular etanercept attenuates pain and hypoxia from TMJ loading in the rat. Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 38(6), 1316–1326. https://doi.org/10.1002/jor.24581