Gianluca De Rosa
Philadelphia
Summary
Biotechnologist with PhD in Human Genetics and professional experience in Molecular Biology, Gene Therapy and Animal work.
Overview
8
8
years of professional experience
Work History
Research Specialist D
University of Pennsylvania
Philadelphia
09.2022 - Current
- Gene Therapy Program, Philadephia
Post-Doctoral Fellowship
University of Pennsylvania
Philadelphia
09.2021 - 09.2022
- Penn Vet
Post-Doctoral Fellowship
Children’s Hospital of Philadelphia
Philadelphia
10.2019 - 09.2021
- Characterization of lentiviral vectors expressing the causative genes of CDA I and CDA II, two diseases affecting the erythroid development, and the establishment of mouse models showing the phenotype of these diseases through the conditional knockout strategy involving the hematopoietic compartment
Graduated fellow
University of Naples “Federico II”
Naples
03.2019 - 09.2019
- Sequencing analysis for diagnostic purposes of samples from hereditary tumors depending on mutations in P53, DICER1, and WT-1 genes
Graduated fellow
University of Naples “Federico II”
Naples
03.2018 - 12.2018
- Description of the effects of mutations of PIEZO1 gene on the phenotype showed by hereditary stomatocytosis, affecting the functions of the red cells and by lymphatic dysplasia
Graduated fellow
University of Naples “Federico II”
Naples
03.2017 - 02.2018
- Assessment of K562 cell model interfered with SEC23B, the causative gene of the disease and treatment with the recombinant protein RAP-011, acting as ligand trap against the cytokine GDF11
Cooperation contract
University of Naples “Federico II”
Naples
05.2016 - 12.2016
- Characterization of a newly discovered protein involved in the pathogenesis of CDAII (ERFE) and the role of the major transcription factor GATA1 in the onset of the disease
Education
Ph.D. - Systems Medicine (Curriculum: Human Genetics)
European School of Molecular Medicine (SEMM), University of Milan
01.2020
Master Degree - Medical Biotechnology
University of Naples “Federico II”
03.2015
Bachelor Degree - Biotechnological Science
University of Naples “Federico II”
10.2012
Erasmus trainership -
CNRS, Montpellier (France)
Skills
- Molecular Biology
- Biochemistry
- Statistics and Bioinformatics
- Animal work
- Teaching and mentoring
Scientificoutput
14 documents (total citations: 374; h-index: 11) in international peer reviewed journals, 4 abstracts in international journals, 1 oral communication at an international meeting, 2017 – Junior Member, “EHA, European Hematology Association”, ATF3 and CH25H regulate effector trogocytosis and anti-tumor activities of endogenous and immunotherapeutic cytotoxic T lymphocytes, Cell Metab, 09/06/2022, Lu Z, McBrearty N, Chen J, Tomar VS, Zhang H, De Rosa G, Tan A, Weljie AM, Beiting DP, Miao Z, George SS, Berger A, Saggu G, Diehl JA, Koumenis C, Fuchs SY, 10.1016/j.cmet.2022.08.007, Tmprss6-ASO as a tool for the treatment of Polycythemia Vera mice, PLoS One, 12/10/2021, Casu C, Liu A, De Rosa G, Low A, Suzuki A, Sinha S, Ginzburg YZ, Abrams C, Aghajan M, Shuling Guo S, Rivella S, 10.1371/journal.pone.0251995, RAP-011 Rescues the Disease Phenotype in a Cellular Model of Congenital Dyserythropoietic Anemia Type II by Inhibiting the SMAD2-3 Pathway, Int J Mol Sci, 08/04/2020, De Rosa G, Andolfo I, Marra R, Manna F, Rosato BE, Iolascon A, Russo R, 10.3390/ijms21155577, Uridine treatment restores the CDA II-like hematological phenotype in a patient with homozygous mutation in the CAD gene, Am J Hematol, 07/28/2020, Russo R, Marra R, Andolfo I, Manna F, De Rosa G, Rosato BE, Radhakrishnan K, Fahey M, Iolascon A, 10.1002/ajh.25946, Gain-of-function mutations in PIEZO1 directly impair hepatic iron metabolism via the inhibition of the BMP/SMADs pathway, Am J Hematol, 11/18/2019, Andolfo I, Rosato BE, Manna F, De Rosa G, Marra R, Gambale A, Girelli D, Russo R, Iolascon A, 10.1002/ajh.25683, The BMP-SMAD pathway mediates the impaired hepatic iron metabolism associated with the ERFE-A260S variant, Am J Hematol, 11/01/2019, Andolfo I, Rosato BE, Marra R, De Rosa G, Manna F, Gambale A, Iolascon A, Russo R, 10.1002/ajh.25613, Germline mutations and new copy number variants among 40 pediatric cancer patients suspected for genetic predisposition, Clin Genet, 07/06/2019, Gambale A, Russo R, Andolfo I, Quaglietta L, De Rosa G, Contestabile V, De Martino L, Genesio R, Pignataro P, Giglio S, Capasso M, Parasole R, Pasini B, Iolascon A, 10.1111/cge.13600, Characterization of Two Cases of Congenital Dyserythropoietic Anemia Type I Shed Light on the Uncharacterized C15orf41 Protein, Front Physiol, 05/22/2019, Russo R, Marra R, Andolfo I, De Rosa G, Rosato BE, Manna F, Gambale A, Raia M, Unal S, Barella S, Iolascon A, 10.3389/fphys.2019.00621, PIEZO1 Hypomorphic Variants in Congenital Lymphatic Dysplasia Cause Shape and Hydration Alterations of Red Blood Cells, Front Physiol, 03/15/2019, Andolfo I, Rosato BE, Manna F, De Rosa G, Marra R, Gambale A, Iolascon A, Russo R, 10.3389/fphys.2019.00258, PIEZO1-R1864H rare variant accounts for a genetic phenotype-modifier role in dehydrated hereditary stomatocytosis, Haematologica, 11/30/2017, Andolfo I, Manna F, De Rosa G, Rosato BE, Gambale A, Tomaiuolo G, Carciati A, Marra R, De Franceschi L, Iolascon A, Russo R, 10.3324/haematol.2017.180687, Characterization of a newly discovered protein involved in the pathogenesis of CDAII (ERFE) and the role of the major transcription factor GATA1 in the onset of the disease, Haematologica, 09/01/2017, Russo R, Andolfo I, Gambale A, De Rosa G, Manna F, Arillo A, Wandroo F, Bisconte MG, Iolascon A, 10.3324/haematol.2016.162966, Novel Gardos channel mutations linked to dehydrated hereditary stomatocytosis (xerocytosis), Am J Hematol, 08/18/2016, Russo R, Andolfo I, Manna F, De Rosa G, De Falco L, Gambale A, Bruno M, Mattè A, Ricchi P, Girelli D, De Franceschi L, Iolascon A, Functional characterization of novel ABCB6 mutations and their clinical implications in familial pseudohyperkalemia, Haematologica, 05/05/2016, Andolfo I, Russo R, Manna F, De Rosa G, Errichiello E, Rosato BE, Gambale A, Vetro A, Calcaterra V, Pelizzo G, De Franceschi L, Zuffardi O, Iolascon A, Novel ABCB6 mutations in familial pseudohyperkalemia cause higher K+ permeability in red blood cells, Haematologica, 05/05/2016, Andolfo I, Russo R, Manna F, De Rosa G, Errichiello E, Rosato BE, Gambale A, Vetro A, Calcaterra V, Pelizzo G, De Franceschi L, Zuffardi O, Iolascon A
Professionalcompetencies
- Molecular Biology
- Biochemistry
- Statistics and Bioinformatics
- Animal work
- Teaching and mentoring
Awards
22th Congress of the European Hematology Association, Travel Grant award
Training
- 22th Congress of the European Hematology Association (EHA 2017), Madrid
- XX Congress of Italian Society of Human Genetics (SIGU 2017), Naples
- XXI Congress of Italian Society of Human Genetics (SIGU 2018), Catania
Languages
Italian
First Language
English
Advanced
C1
Timeline
Research Specialist D
University of Pennsylvania
09.2022 - Current
Post-Doctoral Fellowship
University of Pennsylvania
09.2021 - 09.2022
Post-Doctoral Fellowship
Children’s Hospital of Philadelphia
10.2019 - 09.2021
Graduated fellow
University of Naples “Federico II”
03.2019 - 09.2019
Graduated fellow
University of Naples “Federico II”
03.2018 - 12.2018
Graduated fellow
University of Naples “Federico II”
03.2017 - 02.2018
Cooperation contract
University of Naples “Federico II”
05.2016 - 12.2016
Ph.D. - Systems Medicine (Curriculum: Human Genetics)
European School of Molecular Medicine (SEMM), University of Milan
Master Degree - Medical Biotechnology
University of Naples “Federico II”
Bachelor Degree - Biotechnological Science
University of Naples “Federico II”
Erasmus trainership -
CNRS, Montpellier (France)
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